VetriScience Extra Strength Healthy Hip & Joint Review

Potent clinical strength joint support for senior and active dogs needing advanced mobility maintenance.

Updated January 15, 2026

By Alex Harper

VetriScience Extra Strength Healthy Hip & Joint

VetriScience Extra Strength Healthy Hip & Joint Product Image

Ingredient Transparency:

5 / 5

Scientific Support:

4.5 / 5

Brand Score:

4 / 5

overall Rating:

4.5 / 5

Product Overview

Extra Strength Healthy Hip & Joint (formerly GlycoFlex 3) targets senior dog mobility using Green Lipped Mussel. While the NASC seal confirms quality, the strong marine smell and reliance on internal research are notable downsides. Its transparent, high-potency labeling makes it a strong consideration for advanced joint support.

Key Benefits

  • Manufacturer-funded study reported a 41% increase in hind leg strength.
  • Supports joint comfort and healthy inflammation response.
  • Provides nutrients for cartilage maintenance and joint structure.

Pros

  • Transparent ingredient labeling lists exact dosages
  • NASC quality seal confirms strict safety audits
  • Includes clinical levels of Green Lipped Mussel

Cons

  • Strong marine odor is unpleasant
  • Efficacy claims rely on older internal research
  • Chews can sometimes arrive hard or stale

Bottom line

This high-dose supplement targets stiffness and aging joints. While expensive and smelly, the NASC safety seal and transparent ingredients offer verified value. It is best suited for seniors or working dogs, though buyers should note the efficacy data comes mainly from internal brand research.

Reviews are independent and based on our own research and judgment, but if you buy through links on this page, we may earn a small commission that helps keep our site free.

Let’s Get Started

As dogs age, their mobility needs naturally change. Watching a once-active dog struggle to climb stairs or hesitate before jumping into the car is heartbreaking for any owner.

Joint stiffness is a leading reason owners seek veterinary advice. As a result, the market is flooded with supplements claiming to address these concerns.

VetriScience Extra Strength Healthy Hip & Joint (formerly GlycoFlex 3) stands out in this crowded field. It is frequently recommended by veterinarians for dogs requiring advanced joint support.

This review evaluates the science, safety, and real-world performance of this popular supplement. We will analyze the ingredients and verify marketing claims to help you determine if it fits your dog’s needs.

Product Overview

Extra Strength Healthy Hip & Joint represents the third stage in the VetriScience joint support system. It is specifically formulated for dogs requiring advanced support, such as working dogs, seniors, or those recovering from orthopedic surgeries.

The manufacturer, VetriScience, is a division of FoodScience, LLC, with a long history in the animal health industry. They distinguish themselves by often conducting product-specific research rather than relying solely on general ingredient studies.

The “Extra Strength” designation refers to the high concentration of active ingredients. It combines traditional joint support compounds with the brand’s signature ingredient, Perna canaliculus.

This formulation aims to maintain comfort and flexibility in dogs with advanced joint stress. While widely available without a prescription, it carries a professional reputation often associated with clinical products.

Key Benefits

Here’s a quick look at the main advantages VetriScience Extra Strength Healthy Hip & Joint claims to offer:

  • Supports Back Leg Strength: A manufacturer-funded clinical study reported a 41% increase in strength, helping dogs stand and climb with confidence [1].
  • Maintains Joint Comfort: Research indicates that Green Lipped Mussel helps support a healthy inflammatory response to soothe stiff joints [2].
  • Promotes Cartilage Health: Ingredients supply the necessary building blocks to maintain the structure and function of connective tissue.
  • Supports Immune Function: The formula includes antioxidants that help the immune system manage the oxidative stress associated with joint wear.
  • Enhances Mobility: It is designed to help dogs return to daily activities like running, jumping, and playing.

Ingredient Analysis

The efficacy of any supplement relies entirely on the dosage and quality of its active components. Below is a detailed breakdown of the key ingredients found in the VetriScience Extra Strength Healthy Hip & Joint formula:

  • Perna Canaliculus (Green Lipped Mussel): This is the “powerhouse” ingredient, sourced from New Zealand waters and rich in amino acids and omega fatty acids. According to a study in Evidence-Based Complementary and Alternative Medicine, Green Lipped Mussel can significantly improve comfort and mobility scores [2]. It acts as a natural source of chondroitin to support joint lubrication.
  • Glucosamine HCl (Shrimp and Crab): Glucosamine is a fundamental building block for cartilage that acts as a precursor for glycosaminoglycans. While widely used, a review in the Open Veterinary Journal notes that clinical evidence for glucosamine alone can be conflicting [10]. This highlights the importance of this formula’s multi-ingredient approach.
  • MSM (Methylsulfonylmethane): MSM is a source of organic sulfur, a key component of collagen and connective tissue. A review in the journal Nutrients confirms that MSM is well-tolerated and supports a healthy inflammatory response [7]. It is often paired with glucosamine to support flexibility.
  • N,N-Dimethylglycine HCl (DMG): DMG is an adaptive nutrient that supports immune function, circulation, and the body’s response to physical stress. It is less common in standard joint supplements, representing a unique addition to this formula.
  • Manganese (Mn Proteinate): Manganese is an essential mineral for the formation of collagen and bone. However, an overdose case reported in the Journal of Veterinary Emergency and Critical Care warns that massive ingestion can cause liver failure [8]. This makes secure storage critical.

This formula combines high-quality sources of Green Lipped Mussel and Glucosamine with strict quality controls. Safety is reinforced by the manufacturer’s NASC certification, which mandates rigorous third-party audits for purity and contaminant testing [9]. This external oversight provides verified assurance that the potent ingredients listed on the label are safe for canine consumption.

How It Works

The formula relies on the principle of synergy, meaning the ingredients are intended to work better together than they would individually. While Glucosamine provides the raw materials for maintenance, the Green Lipped Mussel and MSM work to manage the joint environment.

Research suggests the Green Lipped Mussel contains unique omega-3 fatty acids that help modulate the immune system’s response to irritation.

By calming the joint area, the supplement supports comfortable movement. This allows the dog to build muscle, which further stabilizes the joint.

The target audience for this product is specific, and veterinary guidelines generally recommend reserving such high-potency options for advanced care. It is not generally necessary for a young, healthy puppy.

It is primarily designed for senior dogs showing clear signs of slowing down, stiffness upon rising, or reluctance to use stairs. Working dogs, such as hunting or agility competitors that put extreme daily stress on their joints, are also ideal candidates. Finally, it supports pets recovering from orthopedic procedures like CCL repair who need nutritional support for tissue rebuilding.

Safety and Side Effects

Safety is a primary concern for any responsible pet owner. Extra Strength Healthy Hip & Joint is generally considered safe for long-term use in healthy dogs, utilizing natural ingredients often cited in veterinary literature.

The most common side effect reported is digestive upset, including loose stool, gas, or vomiting, often due to the high concentration of marine ingredients. Veterinarians typically suggest introducing the supplement slowly and administering it with a full meal to mitigate these issues.

A more serious safety consideration involves the high palatability of the product. Because the chews taste like treats, dogs may attempt to ingest the entire bag, posing a risk of manganese toxicity. A case report in the Journal of Veterinary Emergency and Critical Care documented acute liver failure after a dog ingested a massive overdose of a similar joint supplement [8].

Consulting a veterinarian before starting this supplement is standard practice. This is especially true if the dog is pregnant, nursing, or taking other medications. While rare, theoretical interactions with clotting disorders or specific diabetes medications exist due to the active ingredients.

Cost and Value

Extra Strength Healthy Hip & Joint is a premium product, carrying a higher price tag than generic glucosamine found at big-box stores. However, the value proposition is supported by the concentration of ingredients.

Budget competitors often utilize “fairy dusting,” a practice where active ingredients are included in negligible amounts. Instead of wasting money on ineffective dosages, the NASC Quality Seal on this package confirms adherence to rigorous facility audits to ensure label accuracy [9].

The value becomes clear when calculating the cost of sourcing high-quality Green Lipped Mussel and MSM separately. The all-in-one chew offers a more cost-effective delivery method for these specific nutrients.

Furthermore, investing in specialized nutritional support can potentially mitigate the financial burden of advanced joint therapies. This makes the upfront cost a worthwhile contribution to your dog’s long-term mobility.

Palatability and Administration

I decided to test these chews with my own dog to get a real feel for the product. He is usually food motivated but can be suspicious of supplements.

When I first opened the bag the smell hit me instantly. It was a strong and distinct marine odor. It reminded me of dried shrimp or low tide at the beach.

The chews themselves were shaped like little bone treats. They felt a bit greasy to the touch. I noticed my fingers had a slight residue after handling them so I made sure to wash my hands immediately.

I tossed one to my dog. He sniffed it for a split second and then inhaled it. There was no hesitation. He actually looked for more. For him this was a high-value treat. I didn’t have to hide it in cheese or peanut butter.

I did notice the texture was a little inconsistent. Most of the chews were soft and pliable but a few at the bottom of the bag felt harder. They crumbled a bit when I tried to break one in half. The resealable strip on the bag was sturdy. Given the strong smell I definitely wanted that bag to stay sealed tight in the pantry.

Overall the administration was incredibly easy. It felt less like giving a pill and more like giving a reward. This is a huge plus for anyone who struggles to pill their dog daily.

VetriScience Extra Strength Healthy Hip & Joint Product Test Photo

Pros and Cons

Here’s a straightforward rundown of what’s great, and not so great, about this product:

Pros:

  • Verified Efficacy: A manufacturer-funded study demonstrated measurable improvement in leg strength [1].
  • Transparent Labeling: Every ingredient amount is clearly listed avoiding hidden proprietary blends.
  • NASC Certified: The manufacturer adheres to strict quality and safety audits [9].
  • High Potency: It contains clinical levels of Green Lipped Mussel that exceed many competitors.
  • Ease of Use: The highly palatable soft chew format simplifies daily dosing for most owners.

Cons:

  • Strong Odor: The potent marine smell can be off-putting to humans.
  • Texture Variability: Chews can sometimes arrive hard or crumbly rather than soft.
  • Digestive Sensitivity: The rich formula may cause loose stool in sensitive dogs if introduced too quickly.
  • Premium Price: It is more expensive than standard maintenance joint supplements.

User Experiences and Testimonials

User feedback for Extra Strength Healthy Hip & Joint is overwhelmingly positive. Analysis of consumer reviews indicates a consensus that this product delivers results. Owners frequently describe a “new dog” effect where seniors regain the ability to climb stairs after four to six weeks.

Many reviews mention that their veterinarian specifically recommended this brand. This reinforces the professional trust behind the product. Owners of dogs recovering from ACL surgeries often credit the supplement with supporting the rehabilitation process.

However the feedback is not without some complaints. The most common negative review focuses on the pungent marine smell. A small minority of users report that their picky dogs refused to eat the soft chew.

Another recurring theme in negative reviews is the texture. Some customers expressed frustration receiving bags where the chews were hard or stale. This suggests occasional issues with inventory rotation or package sealing.

Despite these minor gripes the general sentiment remains high. Most owners feel the visible improvements in their dog’s quality of life are well worth the cost.

Bottom Line

Extra Strength Healthy Hip & Joint stands out as a robust option in the crowded joint supplement market. It moves beyond basic glucosamine to offer a multi-ingredient approach. The combination of high-quality sourcing and manufacturer-funded research validates its reputation.

Consumers should be aware of the higher price point and distinct marine odor. However the transparency of the label and the NASC seal provide verified assurances of safety. These quality controls are often missing in budget alternatives.

This product is best suited for senior dogs, working breeds, or pets recovering from orthopedic surgery. It delivers a potent dose of nutrients intended to support joint structure. For those dealing with advanced mobility issues the potential benefits outweigh the cost.

Product Rating

Here’s how VetriScience Extra Strength Healthy Hip & Joint stacks up:

  • Ingredient Transparency: 5 / 5
    This formulation distinguishes itself by avoiding proprietary blends entirely. Every active ingredient is listed with exact milligram dosages allowing veterinarians to verify the nutrient density. The NASC seal validates the rigorous safety protocols used during manufacturing [9]. This transparency confirms the presence of therapeutic levels of active nutrients rather than fillers hidden behind vague labels.
  • Scientific Support: 4.5 / 5
    The manufacturer-funded study citing a 41% increase in leg strength provides data often missing from generic competitors [1]. While the research is not independent the high-dose Green Lipped Mussel aligns with veterinary consensus on inflammation. This combination offers a potency intended to address advanced mobility issues. The formula is designed for structural support rather than simple preventative care.
  • Brand Score: 4 / 5
    4.0/5 VetriScience maintains a verified history in veterinary clinics establishing a baseline of professional reliability. However persistent consumer reports regarding hard or stale chews indicate potential weaknesses in inventory control. While the clinical reputation is solid the physical product consistency occasionally varies. This variability in texture prevents the product from achieving a perfect score.
  • Overall Rating: 4.5 / 5
    Extra Strength Healthy Hip & Joint functions as a bridge between retail treats and prescription support. It offers a robust solution for dogs with severe needs by utilizing high dosages of active ingredients. The specific focus on senior dogs and post-surgical recovery limits the audience but defines the use case. It is a specialized tool designed for serious joint health challenges.

Frequently Asked Questions

Got questions? We have answers:

According to a manufacturer-funded clinical study conducted at Washington State University dogs showed measurable improvement in hind leg strength after 4 weeks of use [1]. However every dog is different. Some owners report seeing changes in activity levels as early as two weeks while others may take up to six weeks.

This specific Extra Strength formula is typically recommended for senior dogs or those with advanced joint support needs. For young healthy puppies without specific orthopedic concerns a lower-strength maintenance formula might be more appropriate. Veterinary guidelines suggest consulting a professional before starting a puppy on high-dose supplements.

No. The label instructions typically suggest an initial loading dose period of 4 to 6 weeks to build up the ingredient levels in the system. After this period you can reduce the amount to the maintenance dose listed on the package to support joint health long-term.

The most common package size contains 120 soft chews. Depending on the weight of the dog this single bag can last anywhere from one to four months. Always check the label to confirm the count as different retailers may offer varying package sizes.

The bag is made from a durable plastic laminate to preserve freshness and contain the odor. Check the recycling symbol on the back of the package and consult local municipal guidelines. Many flexible plastic pouches are not accepted in curbside bins and may need to be taken to specialized drop-off locations.

The distinct odor comes primarily from the 600 mg of Green Lipped Mussel in each chew. This ingredient is derived from shellfish so a marine or fishy smell is natural. It indicates the presence of the active ingredient rather than spoilage.

They are designed to be soft moist chews. However users frequently report that exposure to air can cause them to harden or become stale. If you receive a bag where the chews are rock-hard upon opening it may be a quality control issue requiring a replacement from the retailer.

No refrigeration is not required. You should store the package in a cool dry place. Ensure the bag is resealed tightly after every use to maintain freshness and texture.

Extra Strength Healthy Hip & Joint (formerly GlycoFlex 3) is a comprehensive formula containing Glucosamine, MSM, and Green Lipped Mussel. Ultimate Strength Healthy Hip & Joint (formerly GlycoFlex Plus) includes all those same ingredients plus Chondroitin Sulfate for maximum joint cushioning. Ultimate Strength also typically comes in a wider variety of flavors like bacon and peanut butter.

They are manufactured in the United States. The parent company is a member of the National Animal Supplement Council (NASC). This membership requires them to pass rigorous quality audits regarding facility standards [9].

Many owners find the cost justified because the formula includes Green Lipped Mussel. This ingredient has stronger evidence for supporting joint comfort than glucosamine alone. A study on Green Lipped Mussel showed significant improvement in dogs with signs of stiffness [2].

Both are high-quality supplements but they use different key ingredients. Cosequin relies heavily on Glucosamine and Chondroitin while this formula relies on those ingredients plus Green Lipped Mussel. If a dog has not responded well to standard glucosamine products the unique mechanism of the mussel extract might offer a different benefit.

If a dog refuses the chew due to the smell or texture try crumbling it into their wet food. Wrapping it in a piece of cheese or deli meat is another common tactic. Some owners also find success by breaking the chew into smaller pieces and mixing it with high-value treats.

The main difference is the delivery method and palatability. The chews contain flavorings to make them taste like treats while the tablets are harder and may need to be hidden in food. The active ingredient profiles are generally similar so the choice depends on the dog’s preference.

The Extra Strength formula features a chicken liver flavor to make the supplement appealing. This savory profile helps most dogs accept the soft chew as a treat. Owners of dogs with known chicken allergies should verify the specific ingredient source on the package before use.

Sources

1. Martinez, S. A., et al. (2006). The effect of Glyco Flex® 3 on stable stifle osteoarthritis in dogs: A pilot study. Washington State University. https://info.vetriscience.com/white_papers/VSL%20120.pdf
  • Provides the core clinical claim that the specific product formulation increased hind leg strength by 41% over a 4 week period.
2. Hielm-Björkman, A., et al. (2009). Evaluating complementary therapies for canine osteoarthritis part I: Green-lipped mussel (Perna canaliculus). Evidence-Based Complementary and Alternative Medicine. https://pubmed.ncbi.nlm.nih.gov/18955269/
  • Supports the efficacy of Green Lipped Mussel, the key ingredient, in significantly improving pain and mobility scores in dogs with chronic osteoarthritis.
3. Rialland, P., et al. (2013). Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Canadian Journal of Veterinary Research. https://pmc.ncbi.nlm.nih.gov/articles/PMC3525174/
  • Validates that diets or supplements rich in Green Lipped Mussel can reduce pain behaviors and improve function in dogs.
4. Aragon, C. L., et al. (2007). Systematic review of clinical trials of treatments for osteoarthritis in dogs. Journal of the American Veterinary Medical Association. https://pubmed.ncbi.nlm.nih.gov/17302547/
  • Offers a broad review of arthritis treatments, noting a moderate level of evidence for Green Lipped Mussel compared to other nutraceuticals.
5. Vandeweerd, J. M., et al. (2012). Systematic review of efficacy of nutraceuticals to alleviate clinical signs of osteoarthritis. Journal of Veterinary Internal Medicine. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1939-1676.2012.00901.x
  • Analyzes multiple studies to conclude that Omega 3 enriched ingredients (like GLM) have better evidentiary support than glucosamine alone.
6. Moreau, M., et al. (2003). Clinical evaluation of a nutraceutical, carprofen and meloxicam for the treatment of dogs with osteoarthritis. The Veterinary Record. https://pubmed.ncbi.nlm.nih.gov/12665145/
  • Highlights the limitations of glucosamine/chondroitin when used without other agents, finding they may not be superior to placebo for pain relief in isolation.
7. Butawan, M., et al. (2017). Methylsulfonylmethane: Applications and safety of a novel dietary supplement. Nutrients. https://pmc.ncbi.nlm.nih.gov/articles/PMC5372953/
  • Confirms the safety profile of MSM and its role in supporting a healthy inflammatory response and oxidative stress management.
8. Borchers, A., et al. (2014). Acute enteral manganese intoxication with hepatic failure due to ingestion of a joint supplement overdose. Journal of Veterinary Emergency and Critical Care. https://pubmed.ncbi.nlm.nih.gov/25080444/
  • Provides the critical safety warning regarding manganese toxicity, illustrating the danger if a dog consumes the entire package of chews at once.
9. National Animal Supplement Council. (2025). NASC Member List: FoodScience, LLC. https://www.nasc.cc/primary-suppliers/foodscience-corporation-vetriscience-laboratories-pet-naturals/
  • Verifies the manufacturer’s active membership in the NASC, serving as a primary “Trust Signal” for quality control and adverse event reporting.
10. Bhathal, A., et al. (2017). Glucosamine and chondroitin use in canines for osteoarthritis: A review. Open Veterinary Journal. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356289/
  • Discusses the conflicting evidence for standard joint ingredients, supporting the need for the multi modal approach (combining them with GLM) found in this product.

Methodology

Our review process is designed to give you confidence when choosing supplements for your dog. We follow four guiding principles: research-backed insights, ingredient transparency, practical guidance, and editorial independence. Every review is written with these standards in mind so you can make informed choices.

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