Purina Pro Plan Veterinary Supplements FortiFlora Review

A highly palatable, stable probiotic powder formulated to support digestive health in dogs.

Updated December 30, 2025

By Alex Harper

Purina Pro Plan Veterinary Supplements FortiFlora

Purina Pro Plan Veterinary Supplements FortiFlora Product Image

Ingredient Transparency:

3.5 / 5

Scientific Support:

4 / 5

Brand Score:

5 / 5

overall Rating:

4 / 5

Product Overview

Purina FortiFlora is a widely recommended probiotic supplement distinguished by its guaranteed bacterial stability and exceptional palatability. It is designed to support immune health and help manage stress-related digestive upset. While highly reliable for these specific uses, the formula relies on animal digest for flavor and offers a lower colony-forming unit (CFU) count than some therapeutic alternatives.

Key Benefits

  • Formulated to support a healthy immune system
  • Supports stool quality and flatulence reduction
  • Encourages appetite through savory flavoring
  • Helps manage diarrhea associated with antibiotic therapy

Pros

  • Verified stability of live bacteria
  • Exceptional palatability for picky eaters
  • Suitable for most puppies and adult dogs

Cons

  • Higher cost per serving than bulk powders
  • Includes animal digest and brewers yeast
  • Lower CFU potency than some clinical competitors

Bottom line

FortiFlora stands out as a reliable, easy-to-administer option for dog owners. While it may not be the most potent probiotic on the market, its proven stability and high acceptance rate make it a top consideration for helping manage common stress-related digestive issues and supporting immune health.

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Let’s Get Started

Dealing with a dog’s upset stomach is one of the most stressful parts of pet ownership. Whether it comes from travel stress or eating something they shouldn’t have, digestive issues are messy and worrying.

Purina Pro Plan Veterinary Supplements FortiFlora is often the first product owners turn to for help. It is widely recognized for its ability to support a healthy immune system and improve stool quality.

However, the pet supplement market is now crowded with advanced new formulas. We evaluated the clinical evidence and real-world owner feedback to see if this industry staple is still the right choice for your dog.

Product Overview

Purina Pro Plan Veterinary Supplements FortiFlora is a probiotic nutritional supplement developed by Nestlé Purina PetCare. It is specifically formulated for the dietary management of dogs and puppies with diarrhea.

Unlike many soft chews or pills found in the pet aisle, this product comes in a box of 30 single-use sachets containing a granular powder. The primary goal of the formulation is to ensure beneficial bacteria arrive alive and active.

The product relies on a proprietary microencapsulation process to protect the microorganisms from moisture and heat. This stability is a critical differentiator in an industry where many products fail to meet their label claims. It is widely available online and in stores without a prescription, though it is sometimes sold by veterinary clinics for specific acute needs.

Key Benefits

Here’s a quick look at the main advantages Purina Pro Plan Veterinary Supplements FortiFlora claims to offer:

  • Supports immune health: A study published in the Journal of Nutrition demonstrates that the specific bacterial strain used in this formula helps boost the immune response, which is particularly beneficial for developing puppies [1].
  • Promotes digestive balance: Clinical studies in the Journal of Veterinary Internal Medicine indicate it effectively reduces the frequency and duration of diarrhea episodes caused by stressful environments like shelters [3].
  • Enhances appetite: The savory animal digest acts as a powerful appetite stimulant. This helps dogs who are feeling nauseous or refusing food to eat their regular meals.
  • Maintains gut stability: According to safety data from the European Food Safety Authority regarding the active bacterial strain, administering this probiotic during antibiotic therapy can help manage disruptions to the gut microbiome [5].
  • Improves Stool Quality: By promoting a healthy balance of intestinal flora, it helps firm up loose stools associated with bacterial imbalance.

Ingredient Analysis

The efficacy of any supplement relies entirely on the dosage and quality of its active components. Below is a detailed breakdown of the key ingredients found in the Purina Pro Plan Veterinary Supplements FortiFlora formula:

  • Active Ingredient (Enterococcus faecium SF68): According to the product label, each packet delivers a guaranteed minimum of 100 million (1×10^8) colony-forming units (CFUs) of this proprietary strain [8]. Purina utilizes microencapsulation technology (visible as small white specks) to ensure this specific strain survives the journey to the canine intestine.
  • Flavoring (Animal Digest): The primary carrier for the probiotic is animal digest, a hydrolyzed poultry or pork source. While the term often raises concerns among owners seeking whole-food ingredients, the hydrolysis process breaks proteins down into smaller peptides. This makes the ingredient highly palatable and often suitable for dogs with food sensitivities, even if the sourcing transparency is a common point of criticism.
  • Brewers Dried Yeast: Included as a carrier and nutrient source. Owners of dogs with specific yeast allergies should be aware of this inclusion.

The most significant “Trust Signal” for this product is the verified stability of its active ingredients. A 2011 assessment published in the Canadian Veterinary Journal found that most commercial pet probiotics failed to contain the bacteria claimed on the label [7]. To address this industry-wide issue, FortiFlora utilizes microencapsulation technology designed to protect the bacteria, allowing the manufacturer to guarantee the viable count at the time of consumption.This protects consumers from “fairy dusting,” a common practice where manufacturers include ingredients at levels too low to be useful. While the use of animal digest is sometimes criticized, it provides a protein source widely regarded as digestible. However, it contributes to a distinctively savory taste profile.

How It Works

To understand if this product fits your dog’s needs, it is helpful to visualize how it functions within the body. The specific strain Enterococcus faecium SF68 acts as a “tourist” in the digestive tract rather than a permanent resident.

According to a review in Veterinary Sciences [10], it does not colonize the gut wall permanently but travels through the intestines to interact with the local immune system. This transient nature explains why consistency is key.

Because the bacteria do not stay in the gut, daily administration is necessary to maintain the population. Veterinarians frequently suggest this product for managing “stress colitis” in dogs.

This condition often strikes when a dog is boarded, travels, or visits the vet. A study in the Journal of Nutrition indicates the supplement is also beneficial for puppies, specifically for supporting immune health during weaning or vaccination series [1].

However, it is not a universal cure. A placebo-controlled trial in the Journal of Veterinary Internal Medicine found that for standard acute diarrhea, the supplement did not statistically shorten the duration of illness compared to a placebo [2].

Additionally, a study in the Journal of Veterinary Internal Medicine confirms it is ineffective against parasitic infections like Giardia [4]. It is best viewed as a stabilizing tool for stress and immune support rather than a cure for severe pathology.

Safety and Side Effects

Safety is a top priority for any pet owner introducing a new bacterial supplement. The safety profile of the SF68 strain has been rigorously evaluated. A report by the European Food Safety Authority (EFSA) confirmed that the strain is safe for use in animal nutrition [5].

According to the EFSA assessment, the strain is suitable for use in puppies, kittens, and adult dogs. However, consulting a veterinarian is recommended when considering this product, particularly before administering live bacteria to pets with severely compromised immune systems.

A review in the Journal of the American Veterinary Medical Association indicates that adverse events are rare and typically mild [6]. Because you are introducing active bacteria, some dogs may experience a temporary increase in gas during the first few days. Beyond these minor initial adjustments, serious adverse reactions are uncommon. The supplement is generally considered suitable for long-term use.

Cost and Value

When evaluating FortiFlora price, there is no denying it sits at a premium point compared to generic tubs of probiotic powder. A box of 30 packets typically costs significantly more per serving than bulk alternatives.

However, the value proposition changes when you consider the “cost of waste.” A 2011 study in the Canadian Veterinary Journal highlights a critical context for this cost: many cheaper veterinary probiotics fail to contain the viable bacteria listed on their labels [7].

This suggests that buying a cheaper tub with inactive bacteria may offer zero value to the consumer. According to Purina’s technical data, the microencapsulation technology is designed to protect the bacteria, allowing the manufacturer to guarantee live organisms will actually reach your dog’s gut [8].

For owners dealing with the stress and mess of a dog with digestive upset, user reviews frequently cite that the reliability of the product justifies the higher daily cost. The individual sachets also prevent the powder from absorbing moisture, a common issue with open tubs.

Palatability and Administration

I decided to give this a shot with my own dog to see if it lived up to the hype. The packets are surprisingly tough but tore open cleanly by hand, so I didn’t have to scramble for scissors.

The powder inside is dark brown with little white specks and hit me with a strong, meaty smell right away. I dumped it over his dry kibble, and it actually coated the pieces really well instead of just disappearing to the bottom of the bowl.

The real verdict came from my dog. He didn’t just eat, he inhaled it.

He spent a solid minute licking the bowl spotless to get every last grain. It worked like a high-value treat topper, which beats fighting him to take a pill any day.

Purina Pro Plan Veterinary Supplements FortiFlora Product Test Image

Pros and Cons

Here’s a straightforward rundown of what’s great, and not so great, about this product:

Pros:

  • Guaranteed Stability: The specialized packaging and microencapsulation allow the manufacturer to guarantee live bacteria when your dog eats them [7].
  • Exceptional Palatability: The animal digest flavor is so effective that it can be used to entice picky or sick dogs to eat their regular food.
  • Proven Safety: Extensive government and veterinary safety assessments confirm the strain is suitable for puppies and adult dogs [5].
  • Convenient Dosing: Single-use packets eliminate the need for measuring scoops and keep the product fresh.

Cons:

  • Lower CFU Count: The 100 million CFU count is significantly lower than some human-grade therapeutic probiotics.
  • Ingredient Perception: The use of animal digest may not appeal to owners who prefer whole-food ingredients or need low-sodium options.
  • Potential Allergen: Contains Brewers Dried Yeast, which may not be suitable for dogs with yeast sensitivities.

User Experiences and Testimonials

Owners consistently describe FortiFlora as a reliable solution for dogs with sensitive stomachs. They frequently praise its ability to help resolve stress-related diarrhea within a few days.

The product is widely celebrated for its palatability. Many users report that even picky eaters view the savory powder as a high-value treat. Owners often use it to encourage dogs to eat their regular meals or to mask the taste of other medications.

While the vast majority of feedback is positive, some critical reviews note that it did not work for severe gastrointestinal issues. A common point of contention is the price, with many finding it expensive for daily use. Side effects are rarely reported, but a small number of users observed increased gas during initial use.

Bottom Line

Our review of the clinical evidence clarifies why this product remains a staple in veterinary medicine. While it is not a universal solution for every gastrointestinal disease, it fills a specific and well-supported role in canine health.

For dogs dealing with “stress colitis” or antibiotic-associated upset, it is a widely recognized option. The combination of guaranteed stability, proven immune support for puppies, and unmatched palatability makes it a strong contender for daily maintenance.

While you might find cheaper options, the peace of mind that comes from using a product with verified stability and safety data offers undeniable value. A systematic review in the Journal of Veterinary Internal Medicine supports the specific utility of this strain for certain conditions [9]. If you are looking for a reliable way to support your dog’s gut health, FortiFlora is a verified option worth considering.

Product Rating

Here’s how Purina Pro Plan Veterinary Supplements FortiFlora stacks up:

  • Ingredient Transparency: 3.5 / 5
    The formulation relies on “animal digest” as the primary ingredient, a generic term that lacks the specificity found in higher-end clean label products. While the 100 million CFU count is lower than many competitors, the use of microencapsulation technology protects these bacteria to help maintain viability through digestion. The ingredient list is safe and functional but does not meet the purity standards some modern consumers expect.
  • Scientific Support: 4 / 5
    This product is backed by robust, strain-specific studies confirming its ability to boost immune health in puppies and reduce diarrhea in shelter environments. However, a key placebo-controlled trial showed it did not statistically shorten the duration of acute diarrhea in dogs compared to a placebo. The evidence supports its use as an immune modulator and stress management tool rather than a rapid cure for all gastrointestinal issues.
  • Brand Score: 5 / 5
    Purina sets the industry benchmark for quality control and manufacturing safety. Independent testing consistently shows this product meets its label claims for live bacteria, a rarity in a market flooded with unstable supplements. The brand’s alignment with rigorous regulatory safety assessments and its status as a widely recommended probiotic reflect a level of reliability and consistency that few competitors can match.
  • Overall Rating: 4 / 5
    FortiFlora acts as a reliable, go-to option for general digestive support and immune health. Its exceptional palatability encourages compliance, making it arguably the easiest supplement to administer. While it may lack the high potency required for severe therapeutic cases, its proven stability and safety make it a trustworthy choice for managing stress-related upset and maintaining gut health during transitions.

Frequently Asked Questions

Got questions? We have answers:

Many owners report observing improvements in stool consistency within a few days of starting the supplement. A study in the Journal of Nutrition demonstrated measurable immune benefits after four weeks of continuous daily use [1].

No, this product does not require refrigeration. The bacteria are protected by microencapsulation technology, which supports stability and viability at room temperature.

Yes, this probiotic is generally considered safe to use alongside antibiotics to help maintain the gut microbiome. According to the European Food Safety Authority [5], experts generally recommend administering the probiotic a few hours apart from the antibiotic dose to support bacterial survival.

Both versions contain the same active bacterial strain, Enterococcus faecium SF68. However, the vitamins and flavoring agents are tailored specifically to the nutritional needs and taste preferences of each species.

Yes, this supplement is widely considered suitable for puppies. Research in the Journal of Nutrition indicates it effectively supports the developing immune system in young dogs [1].

While it is a veterinary-exclusive line often dispensed in clinics, you can purchase it online and at pet specialty retailers without a prescription.

According to the manufacturer’s feeding guide [8], the recommended dosage is one packet per day for all dogs, regardless of their weight or breed size.

Manufacturer product guides define animal digest as a hydrolyzed protein source derived from pork and poultry liver. It is included primarily to provide an intense flavor that supports palatability and compliance [8].

You can sprinkle the powder directly onto dry food. The flavor is potent enough that most dogs will lick it off the kibble, but mixing it with a small amount of wet food can help ensure the full dose is consumed.

The standard formula does not list grains as ingredients, but it is not explicitly certified as grain-free in all regions. Owners with dogs sensitive to specific grains should review the label closely or consult their veterinarian.

The product label indicates it supports intestinal balance, which may help reduce flatulence over time [8]. However, a small number of users report a temporary increase in gas during the first few days of use as the gut adapts.

The higher price reflects the manufacturing technology used to support bacterial survival during storage. Independent testing published in the Canadian Veterinary Journal has shown that FortiFlora consistently meets its label claims for live bacteria, whereas many cheaper alternatives often fail to deliver viable organisms [7].

The animal digest in the product is hydrolyzed, meaning the proteins are broken down into pieces too small for the immune system to typically recognize. However, owners of dogs with known food hypersensitivities should strictly consult a veterinarian before use.

Yogurt contains variable amounts of bacterial strains that may not survive the canine digestive tract. According to a review in Veterinary Sciences [10], FortiFlora provides a guaranteed, stable dose of a specific strain scientifically proven to function in the canine gut.

The standard version is a probiotic only. The PRO Synbiotic Action formula contains the same probiotic strain but includes psyllium fiber as a prebiotic to further support healthy stool quality.

Sources

1. Benyacoub, J., Czarnecki-Maulden, G. L., Cavadini, C., Sauthier, T., Anderson, R. E., Schiffrin, E. J., & von der Weid, T. (2003). Supplementation of food with Enterococcus faecium (SF68) stimulates immune functions in young dogs. The Journal of Nutrition, 133(4), 1158–1162. https://pubmed.ncbi.nlm.nih.gov/12672936/
  • Provides clinical evidence that the specific bacterial strain used in FortiFlora boosts immune response in puppies.
2. Nixon, S. L., Rose, L., & Muller, A. T. (2019). Efficacy of an Enterococcus faecium probiotic for the treatment of acute diarrhea in dogs. Journal of Veterinary Internal Medicine, 33(3), 1286–1294. https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.15481
  • Highlights the limitations of the product, noting that it did not statistically shorten the duration of acute diarrhea compared to a placebo in a controlled trial.
3. Bybee, S. N., Scorza, A. V., & Lappin, M. R. (2011). Effect of the Probiotic Enterococcus faecium SF68 on Presence of Diarrhea in Cats and Dogs Housed in an Animal Shelter. Journal of Veterinary Internal Medicine, 25(4), 856–860. https://pmc.ncbi.nlm.nih.gov/articles/PMC7166405/
  • Demonstrates the effectiveness of the supplement in reducing diarrhea episodes in high-stress environments like animal shelters.
4. Simpson, K. W., Rishniw, M., Bellosa, M., Liotta, J., Lucio-Forster, A., & Bowman, D. D. (2009). Influence of Enterococcus faecium SF68 probiotic on giardiasis in dogs. Journal of Veterinary Internal Medicine, 23(3), 476–481. https://pubmed.ncbi.nlm.nih.gov/19298607/
  • Confirms that the probiotic is ineffective against parasitic infections such as Giardia.
5. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). (2013). Scientific Opinion on the safety and efficacy of Enterococcus faecium (NCIMB 10415) as a feed additive for dogs and cats. EFSA Journal, 11(7), 3363. https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2013.3363
  • Validates the safety of the strain for puppies, kittens, and adult dogs, and provides guidelines for concurrent use with antibiotics.
6. Wynn, S. G. (2009). Probiotics in veterinary practice. Journal of the American Veterinary Medical Association, 234(5), 606–613. https://avmajournals.avma.org/view/journals/javma/234/5/javma.234.5.606.xml
  • Discusses the importance of using specific, verified bacterial strains in veterinary probiotics rather than generic formulations.
7. Weese, J. S. (2011). Assessment of commercial probiotic bacterial contents and label accuracy. Canadian Veterinary Journal, 52(4), 437–440. https://pmc.ncbi.nlm.nih.gov/articles/PMC3003573/
  • Verifies that FortiFlora consistently meets its label claims for live bacteria count, unlike many other commercial pet probiotics.
8. Purina. (2025). Purina Pro Plan Veterinary Supplements FortiFlora Canine Probiotic Supplement. Purina. Retrieved from https://www.purina.com/pro-plan-vet/supplements/fortiflora
  • Source for the specific ingredient list (animal digest), guaranteed analysis (100 million CFU), and administration guidelines for the powder sachets.
9. Jensen, A. P., & Bjørnvad, C. R. (2019). Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review. Journal of Veterinary Internal Medicine, 33(5), 1849–1864. https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.15554
  • A systematic review supporting the utility and safety of specific probiotic strains for maintaining gastrointestinal health.
10. Schmitz, S. S., & Suchodolski, J. S. (2016). Understanding the canine intestinal microbiota and its modification by pro-, pre- and synbiotics. Veterinary Sciences, 3(2), 17. https://pmc.ncbi.nlm.nih.gov/articles/PMC5645859/
  • Explains the mechanism of action, describing how the bacteria act as transient visitors to modify the immune system rather than permanently colonizing the gut.

Methodology

Our review process is designed to give you confidence when choosing supplements for your dog. We follow four guiding principles: research-backed insights, ingredient transparency, practical guidance, and editorial independence. Every review is written with these standards in mind so you can make informed choices.

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